Zheng Wu
Capital University of Physical Educationand Sports, China
Title: Important crosstalk of post-translational modifications in diverse diseases
Biography
Biography: Zheng Wu
Abstract
Multiple post-translational modifications (PTMs) can influence the actions of each other positively or negatively, termed as PTM crosstalk or PTM code. Increasing evidence demonstrates that deregulation of PTMs crosstalk is involved in the genesis and development of various diseases, among which cancer appears to be the most widely studied. In the review, we focused on the crucial roles of PTMs crosstalk in neoplastic diseases and demonstrate their functions by different types of modifications pairs, including the combinations of phosphorylation, acetylation, ubiquitination, SUMOylation and O-GlcNAcylation. For each type of combination, PTMs crosstalk was discussed by positive or negative relashionships, as well as within one protein (intra-protein) or across different proteins (inter-protein). No matter in intra-protein or inter-protein crosstalk, the modifications may influence cancer progress through activation or degradation of the substrates, thereby regulating the pathological development, metastasis, and resistance to chemotherapy of cancer diseases. PTMs crosstalk has been reported in various proteins associated with cancer diseases, such as oncoproteins, tumor suppressors, enzymes and transcription factors. Depending on the modified targets and associated residues in signaling pathways, crosstalk between different proteins could provide abundant promising targets for drug therapy and rehabilitation, as well as biomarkers for clinical diagnosis and prognosis.