42^nd Euro Congress on Cancer Science & Therapy June 08-09, 2022 Rome, Italy

Biography:

Shiro Obata has received MD and PhD in Graduated School of Medicine, Nagasaki University. Currently, he has belonged to Nagasaki Prefecture Shimabara Hospital as Director of Department of Radiology and Radiotherapy from 1995. He received a training of IMRT and stereotactic irradiation in Kyoto University, Department of Medical Physics of Arkansas University, and The University of Texas, MD Anderson Cancer Center for a short term, respectively. His team are developing high precision radiation therapy as IMRT and stereotactic irradiation. His team performed a new treatment, KORTUC for various cancer (280 cases) so far from 2010. He is qualified Radiation Oncologist (JRS and JASTRO), Medical Physicist (JSMP), General Clinical Oncologist (JBCT), and given the title of Clinical Professor of Nagasaki University.

Abstract:

Kochi oxydol radiation therapy for unresectable carcinomas (KORTUC) is a novel cancer treatment method developed in Japan. KORTUC directly targets resistance factors in cancer radiation therapy, such as low-oxygen environments and excessive antioxidant enzymes. This may enhance the effects of conventional radiation therapy. The present study reports the experience of the Nagasaki Prefecture Shimabara Hospital in using KORTUC treatment for a series of 210 patients between January 2010 and June 2019. When this radiosensitizer, a mixture of a dilute hydrogen peroxide solution (0.5 ml, 3%/unit) and sodium hyaluronate (2.5 ml, 0.83%/unit), is administered and applied directly to the cancer lesion, antioxidant enzymes are neutralized and degraded causing reoxygenation as a secondary by-product, thereby enhancing the cytotoxic effect of radiation. The radiosensitizer was administered twice per week before irradiation. As of June 2019, KORTUC was administered to 210 patients. The most common disease stage was stage IV in 137 patients (65%), followed by stage III in 25 patients, stage I in 17 patients and stage II in 7 patients (unknown disease stage in 24 patients). Of the 186 patients who could be followed up after the treatment, 28 (15%) patients had a complete response (by RECIST: Response Evaluation Criteria in Solid Tumors version 1.1), 59 (32%) had a partial response, 73 (39%) had stable disease and 26 (14%) had progressive disease. No significant treatment-related adverse events were observed. The present study highlights the reports of 4 cases (3 cases from among the 28 patients with complete responses): i) A case of advanced, inoperable breast cancer; ii) a refractory patient with recurrence a decade after postoperative irradiation; iii) a patient with advanced, inoperable rectal cancer; and iv) a patient with lymph node metastases. Overall, KORTUC showed good efficacy and tolerable safety for various types of radioresistant solid tumors, and has the potential for immediate worldwide use.

Biography:

Berkan URAL, completed his B.Sc. from TOBB ETU from Electrical Electronics Engineering in 2012. Then, he has been working as a Research Assistant in Gazi University since September 2014. He completed the MSc program from Electrical Electronics Engineering/Biomedical from Gazi University in January 2016. Then, he completed the PhD program from Electrical Electronics Engineering/Biomedical from Gazi University in May 2021. Indeed, he has been working in Kafkas University in Electrical Electronics Engineering; Biomedical, Circuits and Systems since July 2021. His research interest includes Circuits and Systems, Biomedical Electronics and Systems, Image Processing, Deep Learning, Machine Learning, Pattern Recognition, Artificial Intelligence, Bioinformatics, Sleep Studies, Biomedical Signal Processing, Cancer Diagnosis and Computer Aided Diagnosis (CAD) and softwares, C, C++, MATLAB.

Abstract:

This paper presents analysis, evaluation and pre-diagnosis of early stage breast based diagnostic problems (breast cancer, nodules or lumps) by Computer Aided Diagnosing (CAD) system from mammogram radiological images. According to the statistics, the time factor is crucial to discover the disease in the patient (especially in women) as possible as early and fast. In this study, a new algorithm is developed using advanced image processing and deep learning methods to detect and classify the problem at early stage with more accuracy. This system first works with image processing methods (Image acquisition, Noise removal, Region Growing Segmentation, Morphological Operations, Breast Border Extraction, Advanced Segmentation, Obtaining Region Of Interests (ROIs) etc.) and segments the area of interest of breast and then analyzes the separately obtained area for cancer detection/lumps in order to diagnosis the disease. After segmentation, with using the Spectrogram images, 5 different deep learning based methods (specified Convolutional Neural Network (CNN) based AlexNet, ResNet50, VGG16, DenseNet, Xception) are applied to classify the breast based problems.

Biography:

Uri Nir leads the "Cancer metabolism" research lab in the Faculty of Life-Sciences at Bar-Ilan University, Israel. Between the years 2010-2014 he served as the dean of the Faculty. Nir gained his PhD degree from the Weizmann Institute of Sciences in Israel. He then went for a post-doctoral training in the "Hormone-Research Institute" at the University of California San-Francisco, CA., USA. Since 1988 Nir is a faculty member in the Mina and Everard Faculty of Life-Sciences at Bar-Ilan University. The main research interest of the Nir's group is: Identification of key regulators of the reprogrammed energy-generation system of cancer cells and the development of new anti-cancer compounds.

Abstract:

The aspiration to achieve efficacious cancer targeted therapy involves   intense global R&D efforts. Blockage of fundamental processes like the unique reprogramed energy generation system of malignant cells, combined with a nano-technology approach, should offer new tools for efficient interference with cancer progression. While deciphering the energy generation systems of cancer cells we found that two related enzymes (kinases), termed Fer and FerT, which normally reside in the energy power-station-mitochondria of sperm cells, are harnessed to the reprogrammed mitochondria of cancer cells. Both enzymes potentiate the generation of energy by mitochondria in cancer cells subjected to stress conditions like nutrient and oxygen deprivation. This enables the survival of cancer cells under harsh conditions which are prevalent in solid tumors and during metastatic dessimination. To translate these findings into a novel anti-cancer therapy we have combined, synthetic-chemistry, robotic, and high throughput screening approaches, for the development of a synthetic low molecular weight compound which binds and inhibit the kinase activity of both Fer and FerT. Such a compound termed E260 was then formulated and incorporated into nano-micelles to selectively target Fer and FerT in the mitochondria of malignant cells. Notably, the formulated E260 compound selectively and very efficiently perturbs mitochondrial functioning in non-metastatic and metastatic malignant cells, thereby imposing evoking energy crisis and consequent necrotic death in cancer, but not in normal cells. The anti- cancer therapeutic  potency of the E260 formulation is also manifested in-vivo,  against metastatic human tumors derived-xenografts, elicited in mice, thus portraying it as a new potential anti-cancer drug. Accordingly, E260 is now being progressed toward FDA approval for human clinical trials.

Biography:

Ali Khani Jeihooni is affiliated from Department of Public Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. His research interest includes Breast Cancer.

Abstract:

Background:
Breast self-examination (BSE) is an extremely important part of health care for all women in every stage of life. The aim of this study is to survey the application of Theory Planned Behavior (TPB) in doing breast self-examination in women of Fasa City, Fars province, Iran.

Methods:
A cross-sectional study was carried out to examine the factors affecting breast self-examination in 400 women. Then, quasi-experimental research was carried out on 200 subjects (100 in the experimental and 100 in the control group) in 2018-2019. The educational intervention for the experimental group consisted of eight training sessions. A questionnaire consisting of demographic information, knowledge and TPB constructs were used to measure breast self-examination performance before and 6 months after the intervention. Structures of attitude, subjective norms and perceived behavioral control predicted the intention to do breast self-examination in women.

Results:

The studied variables predicted 38.7% of behavioral intention. Six months after the intervention, the experimental group showed a significant increase in the knowledge, attitude, perceived behavioral control, subjective norms, intention, and breast self-examination performance compared to the control group.

Conclusions: This study showed the effectiveness of the intervention based on the TPB constructs in the adoption of breast self-examination performance in 6 months’ post-intervention.

Keywords: Breast self-examination (BSE), Theory Planned Behavior (TPB), Subjective Norms, Women.

Biography:

Ali Khani Jeihooni is affiliated from Department of Public Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. His research interest includes Breast Cancer.

Abstract:

Background:
Breast self-examination (BSE) is an extremely important part of health care for all women in every stage of life. The aim of this study is to survey the application of Theory Planned Behavior (TPB) in doing breast self-examination in women of Fasa City, Fars province, Iran.

Methods:
A cross-sectional study was carried out to examine the factors affecting breast self-examination in 400 women. Then, quasi-experimental research was carried out on 200 subjects (100 in the experimental and 100 in the control group) in 2018-2019. The educational intervention for the experimental group consisted of eight training sessions. A questionnaire consisting of demographic information, knowledge and TPB constructs were used to measure breast self-examination performance before and 6 months after the intervention. Structures of attitude, subjective norms and perceived behavioral control predicted the intention to do breast self-examination in women.

Results:
The studied variables predicted 38.7% of behavioral intention. Six months after the intervention, the experimental group showed a significant increase in the knowledge, attitude, perceived behavioral control, subjective norms, intention, and breast self-examination performance compared to the control group.

Conclusions:
This study showed the effectiveness of the intervention based on the TPB constructs in the adoption of breast self-examination performance in 6 months’ post-intervention.

Keywords: Breast self-examination (BSE), Theory Planned Behavior (TPB), Subjective Norms, Women.

Biography:

Mirna Biglione is a medical doctor specialist in allergy and immunology who has completed her PhD at Buenos Aires University from Argentina. She is a National Referent in Human T Lymphotropic Virus. She has published papers in reputed journals, has been serving as an editorial board member and is the director of the HTLV Group at the “Instituto de Investigaciones Biomédicas en Retrovirus y Sida” (INBIRS) UBA-CONICET. 

Abstract:

Adult T-cell leukemia/lymphoma (ATLL) is a mature peripheral T-cell neoplasm caused by the Human T-cell Leukemia Virus Type 1 (HTLV-1). HTLV-1 infects up to 10 million people worldwide and is most endemic in Southwestern Japan, the Caribbean basin, South America, and Western Africa. ATLL cases were classified according to the Shimoyama criteria into acute (A), lymphomatous (L), chronic (C) and smoldering (S). ATLL carries a dismal prognosis and is essentially incurable by conventional drugs. In the management of aggressive ATLL, chemotherapy remains the preferred choice for L type (with consideration of allo-HSCT upfront), while AZT-IFN is a good option to attempt for A type upfront. The skin is commonly affected in ATLL; 39% to 72% of ATLL patients have skin lesions. Thus, skin lesions may be the first symptom of ATLL, highlighting the importance of early recognition to perform the investigation of HTLV-1 infection.

Only 5% of HTLV-1 infected individuals will develop ATLL and it can be indistinguishable from other more common T-cell lymphomas. HTLV and HIV are human retroviruses that share the transmission route but with different immunopathogeny. HTLV-1 is transmitted sexually in adulthood, however it can be transmitted from mother-to-child perinatally. This can occur transplacentally, during the birth process or via breastmilk. If HTLV-1 is transmitted perinatally then the lifetime risk of ATLL rises from 5% to 20%, therefore prevention of mother-to-child

transmission of HTLV-1 is a public health priority. There are reliable serological and molecular tests available for HTLV-1 diagnosis during pregnancy and screening should be considered in endemic areas and according to history of risk for infection. HTLV-1 is not well known and under-diagnosed because it is not included in Health or Surveillance (international and national) Programmes to prevent infection or to manage its associated diseases. In March 2021, the WHO put forward strategies for the global prevention of HTLV-1 recognizing this virus as a relevant pathogen to humans for the first time.

Biography:

Shahid Ullah is from S Khan Lab Mardan, Pakistan. His research interest includes Cancer

Abstract:

In any field of study, biological databases are the first step. Several databases in cancer research have been published to make it easier and faster for the cancer research community. By sharing a common parameter with different search engines, we were able to collect practically all research databases into one platform named CHCRD. The first stage in creating a successful observational database was to create a research database structure that included data items. We defined the important categories of the cancer databases to which readers want answers, and data elements need to be captured. The second phase was to compare various data collection methods and make recommendations for more efficient ones. Data capture with minimal human effort is a critical step in maintaining a database for a long time. The goal of this study is to offer a multi-center observational cancer research database structure that includes all cancer research data, as well as to recommend effective data collection methods that are linked to clinical information systems. Our goal is to create a research database system with accessible data access, clear scientific reproducibility, and cross-center interoperability. The database is created using computer platforms like as PHP, HTML CSC, and JavaScript.

Keywords: Cancer, CHCRD, Cancer database, S Khan Lab

Biography:

Fariba Yazdanpanah is affiliated from department of Internal Medicine in the University of Maryland Capital Region Medical Center, USA. Her research interest includes Breast Cancer, Organ specified Cancers.

Abstract:

A 78-year-old, African American, legally blind female presented to the emergency department following recurrent mechanical falls. The patient’s past medical history was significant for atrial fibrillation, diabetes mellitus, hypertension, and hyperlipidemia and her family history was remarkable for ovarian cancer in her sister and prostate cancer in her brother. On physical exam, a large, necrotic, fungating, right breast mass with purulent drainage was found (Figure 1). The onset, per patient, was 4-5 months prior to presentation and the patient never had it evaluated. Chest computed tomography (CT) scan with contrast revealed a large ulcerating right breast tumor (14 x 6 x 11 cm) with infiltration of the right chest wall musculature (Figure 2), large right axillary lymph node metastases, and multiple pulmonary metastatic lesions (compatible with a stage T4b N3 M1 lesion). The patient underwent a core-needle biopsy, and the report showed invasive ductal carcinoma grade 2 (Figure 3). The immunohistochemical stain for E-cadherin was positive confirming the ductal phenotype (Figure 4). As per the current College of American Pathologists (CAP) and American Society of Clinical Oncology (ASCO) criteria, hormone receptor testing was done and resulted with Estrogen Receptor (ER): Negative, Progesterone Receptor (PgR): Positive (Percentage of cells with nuclear positivity: <5%), and Human Epidermal growth factor Receptor 2 (HER2): Negative. The patient was considered for systemic chemotherapy and breast-conserving therapy (BCT) via radiation therapy to palliate symptoms, prolong survival, and maintain quality of life.

Biography:

Sophie badzgaradze did her studies from 1992-1998 in institute of Critical Care Medicine at Tbilisi medical State University. In 2010 she completed her PhD at American University in Tbilisi. She did her training courses such as: The Basics of Homotoxicology in the Rheumatology and Gastroenterology, Symposium - "Modern Aspects of Bioregulation Medicine", Modern Clinical Medicine, Achievements and Latest Technologies, Scientific Practical Relations in Medicine - Reality and Perspectives, 34^th Euro Global Summit on Cancer Therapy and Radiation oncology, 37^th Conference of the International Clinical Hyperthermia Society and many other courses.

Abstract: