40^th Euro Congress on Cancer Science & Therapy May 25-26, 2020 Rome, Italy

Biography:

Sang Youn Hwang is currently affiliated to the Department of Internal Medicine and Gastrointestinal Cancer Centre in Dongnam Institute of Radiological & Medical Sciences, Republic of Korea.

Abstract:

Background: Cabozantinib is approved as second line therapy in patients with progression after sorafenib in hepatocellular carcinoma (HCC) patients, however the study about efficacy of cabozantinib as third or fourth line therapy (esp. in the case of progression after nivolumab). We aimed to evaluate the efficacy and safety of cabozantinib as 3rd & 4th line treatment in patients with advanced HCC with progressive disease after TKI and nivolumab.

Methods: Eligible advanced HCC patients with documented radiological evidence of disease progression with previous 1st & 2nd line systemic treatment were recruited in our hospital from Mar 2019 to Aug 2019. All patients initially received cabozantinib 60mg daily as fixed starting dose every 4 weeks for unlimited cycles untile radiologic progression.

Results:  Six patients (3rd line Tx in one patient, 4th line Tx in five patients) were enrolled in the study. All five patients previously received three sequential therapies (sorafenib → regorafenib → nivolumab) and only one patient received two sequential therapies (sorafenib → nivolumab). The median level of AFP was 128.6 ng/mL (1.3-20948), that of PIVKA was 2131 mAU/Ml (1057-29440) in 2L group. The median OS was 5 months (range 3-6.5) and the median PFS was 4 months (range 3-6.5). The OS and in sorafenib responder & non responder were not different significantly (median OS 4 vs 3 months; p-value=0.503). All patient achieved stable disease. Grade 3 or 4 adverse events occurred in 3 patients (66.6%). The most common high-grade events fatigue (50%) and diarrhea (16%). Interruption of drug was happened in all patients within 8 weeks and dose reduction was occurred in 4 patients (66.6%).

Conclusions: Our study suggests that cabozantinib can be relatively effective and safe strategy as 3rd and 4th line therapy in HCC patients refractory for previous systemic therapy. A further well controlled, large scaled study to prove survival benefit is recommended. 

Biography:

Zheng Wu has completed her MD at the age of 27 years from Peking University Health Science Center. She has been serving as a lecturer in School of Kinesiology and Health in Capital University of Physical Education and Sports since 2017. She has published 3 papers in SCI journals as the first author.

Abstract:

Multiple post-translational modifications (PTMs) can influence the actions of each other positively or negatively, termed as PTM crosstalk or PTM code. Increasing evidence demonstrates that deregulation of PTMs crosstalk is involved in the genesis and development of various diseases, among which cancer appears to be the most widely studied. In the review, we focused on the crucial roles of PTMs crosstalk in neoplastic diseases and demonstrate their functions by different types of modifications pairs, including the combinations of phosphorylation, acetylation, ubiquitination, SUMOylation and O-GlcNAcylation. For each type of combination, PTMs crosstalk was discussed by positive or negative relashionships, as well as within one protein (intra-protein) or across different proteins (inter-protein). No matter in intra-protein or inter-protein crosstalk, the modifications may influence cancer progress through activation or degradation of the substrates, thereby regulating the pathological development, metastasis, and resistance to chemotherapy of cancer diseases. PTMs crosstalk has been reported in various proteins associated with cancer diseases, such as oncoproteins, tumor suppressors, enzymes and transcription factors. Depending on the modified targets and associated residues in signaling pathways, crosstalk between different proteins could provide abundant promising targets for drug therapy and rehabilitation, as well as biomarkers for clinical diagnosis and prognosis.

Biography:

Agnieszka Fus-Kujawa has completed her Masters at the age of 24 years from University of Silesia in Katowice and has started her doctoral studies from Medical University of Silesia in Katowice in Department of Molecular Biology and Genetics. She is the assistant and has opened her doctoral thesis on March 2019. She has published in journals with Impact Factor and actively participates in scientific Conferences.

Abstract:

Efficient and controlled delivery of nucleic acids by viral and synthetic carriers with low toxicity is one of the most important challenges facing the gene therapy. Nonviral vectors are perfect candidates for this goal because the use of viral vectors have a high risk of inducing unwanted immune responses. For medical applications, a use of nanostructured polymers every year brings more and more possibilities. The creation of new polymers and the study of their biocompatibility is very important to find better and safer vectors for gene therapy. In this work we compared conventional transfection and deposition transfection performed with the use of cationic star polymer. Obtained polyplexes were tested for cytotoxicity and luciferase activity using HT-1080 cells as a model. One of the solutions to increase transfection efficiency seems to be the deposition of the nucleic acid itself or its polyplex on solid support. The support used for the purpose is functioning as a substrate supporting the organization and differentiation of cells, while immobilized DNA or RNA delivers significant genetic information into the cells. The major advantages of the immobilization of nucleic acid/polyplexes include the direct contact of polymer layer loaded with the nucleic acid with the cells during the proliferation.The performed studies demonstrated that we obtained the novel effective system, based upon star polymer architecture, which is potentially useful for gene delivery. This work was supported by the Polish National Science Center contract no. UMO-2015/17/B/ST5/01095.

Biography:

Donato Gemmati is professor in Medical Genetics, Section of Medical Biochemistry, Molecular Biology & Genetics, University of Ferrara, Italy and Director of the Interdepartmental Research Center of Haemostasis & Thrombosis, University of Ferrara, Italy. He was born in Rome, Italy (12 Jan 1963), Specialized in Medical Genetics (2006) and PhD in Biomedical Sciences (2009), University of Ferrara, Italy. Board member of the Molecular Medicine PhD Course, University of Ferrara, Italy. Editorial board member: ì. International Journal of Molecular Sciences (Molecular Genetics and Genomics section); ìì. Genes (Human Genomics and Genetic Diseases section).

Abstract:

Inherited thrombophilia (i.e. venous thromboembolism, VTE) is due to rare genetic loss-of-function mutations, common genetic risk factors and acquired risk conditions, modulating onset age, severity, recurrence and penetrance of the main gene defect also within the same kindred. GWAS recently recognized about 1000 genes associated to VTE thought some gene defects may unpredictably remain asymptomatic, so calculating the individual genetic predisposition is a challenging task. Uncommon loss-of-function mutations in SERPINC1, PROC or PROS1 genes and common gain-of-function mutations in F5 (rs6025) or F2 (rs1799963) genes, are the key genetic risk factors. By multilocus genetic approach, we investigated a large family (68 members) characterized by severe VTE despite of life-long anticoagulant treatment. The main defects found were a common missense mutation (c.G1691A) in the exon_10 of F5 gene (p.R506Q, i.e. FV Leiden) and a type 1 antithrombin (AT) deficiency caused by a nonsense mutation (CGA>TGA) responsible for a premature stop codon (c.1171C>T; p.R391X) in the exon_6 of SERPINC1 gene.

Cosegregation of both mutations was found in the propositus and in 18 (26.4%) family members, and the mutations never appeared as single-defect. SERPINC1 (1q25.1) and F5 (1q24.2) genes are very close in the long arm of chromosome 1, and the hypothesized cis-segregation was confirmed in all the carriers by linkage analysis of STR-(ATT)5-18 in the SERPINC1 IVS_5. Detailed studies in a branch of this family, revealed that the proposita had VTE after surgery (20y); one of her brothers had spontaneous VTE (21y) as well one of his sons after surgery (14y). Both his daughters had early VTE episodes and complicated pregnancies: ì. the older had bilateral VTE (29y) and perinatal renal thrombosis in the newborn characterized by in-utero origin; ìì. the younger had massive VTE and cerebral ictus (23y) requiring premature life-saving pregnancy-interruption. Molecular analyses performed in the newborn of the first daughter and in the aborted tissues from the second daughter confirmed the SERPINC1-F5 combined defect in both progenies. A multilocus-genetic approach performed in this branch of the family also included: F5 (rs1800595); F12 rs1801020; F13A1 rs5985; SERPINC1 rs121909548; SERPINA10 rs2232698; ABO rs8176719; F11 rs2036914; FGG rs2066865; KNG1 rs710446; F11 rs2289252. We found early VTE onset and recurrence being associated to FGG rs2066865 and F5 rs4524; whilst F5 (rs1800595) was fond in trans with F5 (rs6025) in the post-mortem analysis of the in-utero thrombosis material. The common F5 rs1800595 strongly synergizes with F5 rs6025 becoming a life-threatening condition when combined with SERPINC1 mutations. Merging classic and newly GWAS-identified genetic markers is mandatory for a complete and accurate VTE risk estimation and patient management in the clinical practice to avoid partial risk score estimation in unrecognized at risk patients.

Biography:

Veronica Tisato has completed her PhD from Padua University, Italy. Post-doctoral experience in Ferrara University, she is professor of Human Anatomy. Interests: Translational research, Gender Medicine, Regenerative Medicine, Personalized and Precision Medicine. Focus on inflammation and biomarkers in cardiovascular and complex diseases, aging, neurodegenerative/cognitive impairment diseases. Editorial board member of International Journal of Molecular Sciences.

Abstract:

In December 2019, a novel severe acute respiratory syndrome (SARS) from a new coronavirus (CoV-2) was recognized in the city of Wuhan, (China). Rapidly, it became epidemic in China and it has now a worldwide diffusion reaching pandemic proportions. High death rate characterizes CoV-2 disease (COVID-19) particularly striking elderly causing unrestrained cytokines-storm and consequent pulmonary shutdown. At the moment, no specific and dedicated treatments, neither approved vaccines are available, though very promising researches come from the side of anti-inflammatory and anti-malaria drugs. In addition, it seems that males are more susceptible to CoV-2 than females, with 65% more likely to die from the infection than females. Data from the World Health Organization (WHO) and Chinese scientists show that of all affected cases about 1.7% of women who contract the virus will die compared with 2.8% of men and data from Hong Kong hospitals state that 32% of male and 15% of female COVID-19 patients required intensive care or died.

Conversely, in the long term the coronavirus fallout may be worse for women than men due to social and psychosocial reasons. Regardless the sex- or gender-gap data obtained from WHO and those recruited from scientific journals sometimes controversial, some central points should be considered. Firstly, CoV-2 has a strong interaction with human ACE2 receptor playing essential role in cell entry; interestingly the ACE2 gene lays on the X-chromosome rendering females potentially heterozygous and differently assorted versus men definitely hemizygotes. Secondly, the highest ACE2 expression rate in females, though controversial, might ascribe them the worst prognosis, in contrast with worldwide epidemiological data. Finally, the several genes involved in inflammation are located on the X-chromosome, which also contains high number of immune-related genes responsible for innate and adaptive immune responses to infection. Summarizing, X-heterozygous females might activate a mosaic advantage and higher sexual dimorphism than males to counteract CoV-2 infection progression, and unexpectedly, higher ACE2 levels, or ACE/ACE2 rebalancing, might ameliorate COVID-19 outcome being protective against CoV-2 fatality.

Biography:

Abeera Mehmood is a PhD, professor from Yusra Institute of Pharmaceutical Sciences (YIPS), Islamabad, Pakistan and recently submitted case report of a rare malignancy in children based on the title small round blue cell tumors, management dilemma: A case report on Alveolar Rhabdomyosarcoma in a four year old child. Her research interest focuses on malignancy, rhabdomyosarcoma and cell tumour.

Abstract:

Rhabdomyosarcoma is one of the small round blue cell tumors, and though rare, it is the most common soft tissue sarcoma in children. Similar microscopic appearance and similar histochemistry makes differentiation and diagnosis very difficult in these lesions. Here we report a case of a 4 year old boy, who presented with an abdominal mass. Initial investigations confirmed presence of heterogeneously enhancing pelvic mass with no metastasis or local extension. It was confirmed to be Rhabdomyosarcoma on ultrasound guided biopsies, though further differentiation was not possible. Patient responded well to initial treatment in the form neo adjuvant chemotherapy with significant reduction in size of tumor. After subsequent surgical resection, the child had a relapse of disease while he was still on adjuvant chemotherapy. The aim to report this case is to highlight the problems associated with diagnosis and management of this rare disease. 

Biography:

Eleni Petsalaki has completed her PhD at the age of 28 years at the University of Crete. She is currently a post doctoral research scientist in Dr George Zachos’ Cell Cycle and Division Lab at the University of Crete where she is investigating mechanisms of mitotic cell division in human cells. She has published 8 papers in peer reviewed journals including Nature Communications, Journal of Cell Biology, Journal of Cell Science and others, 2 review articles and 2 commentaries.

Abstract:

The mitotic spindle consists mainly of microtubules (MTs) and is essential for accurate distribution of chromosomes in the two daughter cells during cell division. Errors in spindle formation can lead to incorrect separation of chromosomes or unequal size of daughter cells, which are associated with carcinogenesis or developmental disorders. However, the molecular mechanisms of spindle formation are not fully understood. In the present study, we show for the first time that Chk1, a kinase involved in the cellular response to DNA damage, is essential for optimal density and effective polymerisation of the spindle MTs in human cells. Chk1 localises to the centrosomes (the main centers of MTs organization) in mitosis and phosphorylates β-tubulin in newly identified sites in vitro. Also, reduced microtubule density in cells without functional Chk1 is associated with formation of disorganized spindles. We suggest that Chk1 phosphorylates β-tubulin to promote optimal spindle MT polymerisation. These findings describe novel mechanisms that could protect against carcinogenesis and developmental disorders, through regulating formation of the mitotic spindle

Biography:

Jenea Bintey Khan is a Bio-medical engineer and recently she is working on National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh in the department of radiotherapy and have recently focus on the article on Commissioning of a Flattening Filter Free (FFF) using an anisotropic analytical algorithm.

Abstract:

Aim: To compare the dosimetric parameters of the flattened and flattening filter free (FFF) beam and to validate the beam data using anisotropic analytical algorithm (AAA).

Materials and Methods:  All the dosimetric data’s (i.e. depth dose profiles, profile curves, output factors, penumbra etc.) required for the beam modeling of AAA were acquired using the Blue Phantom RFA for 6MV, 6FFF, 10MV & 10FFF. Progressive resolution Optimizer and Dose Volume Optimizer algorithm for VMAT and IMRT were are also configured in the beam model. Beam modeling of the AAA were compared with the measured datasets.

Results: Due to the higher and lover energy component in 6FFF and 10FFF the surface doses are 10 to 12% higher compared to flattened 6MV and 10MV beams. FFF beam has a lower mean energy compared to the flattened beam and the beam quality index were 6MV 0.667, 6FFF 0.629, 10MV 0.74 and 10FFF 0.695 respectively. Gamma evaluation with +2% dose and 2mm distance criteria for the Open Beam, IMRT and VMAT plans were also performed and found a good agreement between the modeled and measured data.

Conclusion: We have successfully modeled the AAA algorithm for the flattened and FFF beams and achieved a good agreement with the calculated and measured value

Biography:

Muhammad Usman, a former Director General of Agricultural Research System, Government of Pakistan who retired from service after a spotless career of about 32 years with senior level experience on research and development of integrated agricultural production, industries, Agriculture & Horticulture and bioenergy on a sustainable way, He established Prominent Agro Based Industries, Agro Based Industries and Consultancy SDN BHD in Malaysia and Foundation for Rural Development in Pakistan with primary aim to work on integrated agricultural project for rural development through improvement in agriculture and consultancy services to the farmers at Malaysia.

Abstract:

The aim of presentation consist of oncology, Cancer Science, therapy, health different types of cancer were studied and reported that Oncology Cancer Science and Therapy is the major tools for the development health as well as to control the different types of cancer diseases in the world.   The study reported that the world oncology consist of two parts i.e “onco” means bulk, mass, or tumor while “logy” means study. Therefore oncology is known is the study of tumors or different type of cancer diseases. In other words, oncology is the branch of science that deals with the tumor and cancer diseases. The study also reported that oncology is the study of cancer and it treatment in medical science. The study further reported that cancer is a group more than 100 different disease. Cancer is very serious disease as it can developed almost anywhere in the body. The most important oncology diagnostic remains the clinical history of the patient. Common symptoms that point towards cancer include fatigue, weight loss, unexplained anemia, fever of unknown origin etc. Oncology depends on diagnostic tools like biopsy or removal of bits of the tumors tissue and examining it under the microscope. Other diagnostic tools include endoscopy for the gastrointestinal tract, imaging studies like X-rays, CT scanning, MRI scanning, ultrasound and other radiological techniques, Scintigraphy, Single Photon Emission Computed Tomography, Positron emission tomography and nuclear medicine techniques etc. The oncologist’s role including explaining the cancer diagnosis and stage to the patient. Discussing all the relevant treatment options and the oncologist’s recommendations. In other words Cancer Science a disease caused by an uncontrolled division of abnormal cells in a part of the body. Further reported that a malignant growth or tumor resulting from an uncontrolled division of cells. Similarly Cancer therapy describes the treatment of cancer in a patient, often with surgery, chemotherapy and/or radiotherapy. Targeted therapies are also available for some cancer types.

The study reported that the total countries available in the world are 225, consist of (Developed countries = 49, developing countries = 150, observer state = 4, state without partial recognition = 8, unrecognized state = 14). Similarly, South Asia comprises the countries of Pakistan, Bangladesh, India, Bhutan,

Maldives, Nepal and Sri Lanka.  In the light of above study, it is proposed that Cancer Science and Therapy should be commercialized  for the development of health, basic need of daily life, create employment, generate income, stronger economy, reducing financial crises, global Poverty and hunger in the developing countries of the world particularly in south Asia

Biography:

Muhammad Usman, a former Director General of Agricultural Research System, Government of Pakistan who retired from service after a spotless career of about 32 years with senior level experience on research and development of integrated agricultural production, industries, Agriculture & Horticulture and bioenergy on a sustainable way, He established Prominent Agro Based Industries, Agro Based Industries and Consultancy SDN BHD in Malaysia and Foundation for Rural Development in Pakistan with primary aim to work on integrated agricultural project for rural development through improvement in agriculture and consultancy services to the farmers at Malaysia.

Abstract:

The aim of presentation consist of oncology, Cancer Science, therapy, health different types of cancer were studied and reported that Oncology Cancer Science and Therapy is the major tools for the development health as well as to control the different types of cancer diseases in the world.   The study reported that the world oncology consist of two parts i.e “onco” means bulk, mass, or tumor while “logy” means study. Therefore oncology is known is the study of tumors or different type of cancer diseases. In other words, oncology is the branch of science that deals with the tumor and cancer diseases. The study also reported that oncology is the study of cancer and it treatment in medical science. The study further reported that cancer is a group more than 100 different disease. Cancer is very serious disease as it can developed almost anywhere in the body. The most important oncology diagnostic remains the clinical history of the patient. Common symptoms that point towards cancer include fatigue, weight loss, unexplained anemia, fever of unknown origin etc. Oncology depends on diagnostic tools like biopsy or removal of bits of the tumors tissue and examining it under the microscope. Other diagnostic tools include endoscopy for the gastrointestinal tract, imaging studies like X-rays, CT scanning, MRI scanning, ultrasound and other radiological techniques, Scintigraphy, Single Photon Emission Computed Tomography, Positron emission tomography and nuclear medicine techniques etc. The oncologist’s role including explaining the cancer diagnosis and stage to the patient. Discussing all the relevant treatment options and the oncologist’s recommendations. In other words Cancer Science a disease caused by an uncontrolled division of abnormal cells in a part of the body. Further reported that a malignant growth or tumor resulting from an uncontrolled division of cells. Similarly Cancer therapy describes the treatment of cancer in a patient, often with surgery, chemotherapy and/or radiotherapy. Targeted therapies are also available for some cancer types.

The study reported that the total countries available in the world are 225, consist of (Developed countries = 49, developing countries = 150, observer state = 4, state without partial recognition = 8, unrecognized state = 14). Similarly, South Asia comprises the countries of Pakistan, Bangladesh, India, Bhutan,

Maldives, Nepal and Sri Lanka.  In the light of above study, it is proposed that Cancer Science and Therapy should be commercialized  for the development of health, basic need of daily life, create employment, generate income, stronger economy, reducing financial crises, global Poverty and hunger in the developing countries of the world particularly in south Asia

Biography:

Russell I. Heigh joined Mayo Clinic in Arizona in 1988. He received his M.D. degree from Upstate Medical University, State University of New York. He completed his Internship/Residency in Internal Medicine along with a Fellowship in Gastroenterology at George Washington University Medical School. He held senior leadership positions within the profession and within Mayo Clinic. Currently, he is a medical director of Legislative Affairs for Arizona. He has a large clinical practice focusing on helping patients with inflammatory bowel disease and colorectal neoplasia, actively participates in clinical research and is a frequent speaker on these topics.

Abstract:

Inflammatory Bowel Disease, including both Chronic Ulcerative Colitis and Crohns Disease, is a set of commonly encountered clinical conditions.  It is estimated that the conditions have prevalence approximately 250-300/100,000 in the USA. Unfortunately, over the last decade the incidence of Inflammatory Bowel Disease is increasing in much of the world. Inflammatory Bowel Disease is associated with both intestinal and extra intestinal malignancies. Some of the therapies frequently used to treat the medical condition are themselves also associated with increased development of malignancies. This discussion will review the current spectrum, status and issues related to the malignancies experienced by patients with Inflammatory Bowel Disease. Additionally, efforts at prevention and early detection of malignancy will be described. Monitoring opportunities, surveillance programs, and the role of the new chromo colonoscopy will be reviewed

Biography:

Shi-Jun Xu has completed her PhD at the age of 30 years from Sun Yat-sen University. She is the key member of Cancer Research Group in Radiology Department, National First-level Disciplines in Henan Cancer Hospital. She has published 3 papers in reputed journals.

Abstract:

The tumor microenvironment (TME) is the primary arena where tumor cells and the host immune system interact. Bidirectional communication between tumor cells and the associated stromal cell types within the TME influences disease initiation and progression, as well as tumor immunity. There are multiple types of stromal cells and among them, macrophages and natural killer (NK) cells are the most prevalent. They not only are key players in innate immunity which serves as the first barrier against pathogen infection and as the bridge to connect adaptive immunity, but also play important roles in tumor immunity. Besides, epithelial cells, such as hepatocytes in liver, perform robust innate immune response against pathogen infection and tumor initiation. More importantly, these cells display either pro- or anti-tumor properties, depending on the expression of key regulators. MicroRNAs (miRNAs) are emerging as such regulators. They affect not only immune cells but also epithelial cells whose functions closely related to pathogen infection, tumor initiation and tumor evasion of the immune system. In this review we will discuss the role of miRNAs in tumor immunity, focusing particularly on innate immunity related cells such as macrophages, NK cells and hepatocytes.

Biography:

Subhasis Misra, MD is a Surgical Oncology Specialist in Brandon, FL.  He is affiliated with medical facilities Brandon Regional Hospital and Northwest Texas Healthcare System.  He is accepting new patients and has indicated that he accepts telehealth appointments.

Abstract:

Introduction: Parathyroid cancer (PC) is an extremely uncommon malignancy with a frequency of 0.005% of all the malignancies and also contributes almost 0.74%-4.7% of all the hyperparathyroidism. Most of the manifestations of the PC are mainly secondary to its complications, including hypercalcemia, nephrolithiasis, peptic ulcer disease (PUD), and bone pathologies. Most of the data related to this rare disease is limited to case series and very few database studies. To the best of our knowledge, we present the largest database study which aims to investigate the demographic, clinical, and pathological factors impacting prognosis and survival of PC.

Methods: Demographic and clinical data of 609 patients with PC was abstracted from the Surveillance Epidemiology and End Result (SEER) database (1975 – 2016). Chi-square test, paired t-test, and cox regression multivariate analysis was used to analyze the data.

Results: The PC had a higher incidence amongst males (52.2%, p<0.005), Caucasians (75.4%, p<0.005), and had a mean age of diagnosis 62±10 years. When grading information was reported, most of the PC was the well-differentiated tumors (Grade 1) (9.3 %) and had Adenocarcinoma NOS histological type (99.7%), p=<0.005. When reported, most of PC were 2-4cm cm in size (56.6 %) and were localized to the gland (65.5 %), p=<0.001. Lymph nodes were only positive in 2.3 % of the entire cohort. Most PC patients were treated surgically (97.2%), followed by the radiation alone (12%), and very few patients received chemotherapy (0.9 %). The 5-year overall observed survival for PC was 82.7 %, while those who underwent surgery only and radiation alone had a 5- year survival of  83.8 %, and 72.2 %, respectively, P=0.037. Multivariate analysis identified age, gender, distant spread, and poorly differentiated histology poorly differentiated grade to be independently associated with increased mortality for PC, p<0.001.

Conclusion: PC is a rare tumor that mostly affects patients in their 6th decade and primarily affects men and Caucasians. Surgical resection offers the optimal survival advantage, while the radiation alone or in combination with surgery does not

provide added survival benefits. To understand better the pathogenesis and factors impacting the survival, all patients diagnosed with PC should be enrolled in a large-scale to the national and international registries.

Biography:

Jin has completed his MD at the age of 35 years from Capital Medical University. He is the director of Ultrasound Department of Guilin Medical University. He has published more than 30 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

The study developed a modified TI-RADS score using gray-scale ultrasound, contrast-enhanced ultrasound (CEUS), and shear-wave elastography (SWE) images to predict malignancy of thyroid nodules and compared this modified score system with the subjective scoring criteria based on ACR TI-RADS (2017 edition). By using SWE and CEUS (enhanced pattern) to downgrade TI-RADS category 4 and 5 nodules, the malignancy rate for TI-RADS category 4 and 5 nodules increased from 47.6% with ACR TI-RADS assessment alone to 49.4% with ACR TI-RADS combined SWE and CEUS (enhanced pattern). Likewise, by using the modified TI-RADS to adjust TI-RADS category 3 nodules, the malignancy rate for TI-RADS category 3 nodules increased from 13.9% to 20.0%. Interestingly, applying the modified TI-RADS to adjust TI-RADS category 4 or 5 nodules, the malignancy rate for TI-RADS category 4 or 5 nodules decreased from 31.0% or 75.4% with ACR TI-RADS assessment alone to 27.8%  or 72.9% with ACR TI-RADS combined SWE and CEUS (enhanced pattern). The discriminating power for detection of malignancy of the variable score 2, with an AUC of 0.899 (95% CI, 86.1%-93.6%), was higher than that of score 1, with an AUC of 0.862 (95% CI, 81.9%-90.6%; P > 0.05). With a point 4.5 as the optimal cutoff value, a score of 1 (ACR TI-RADS) predicted malignancy with an accuracy of 75.6%, sensitivity of 85.0%, and specificity of 71.6%. However, with a point 5.5 as the optimal cutoff value, a score of 2 (ACR TI-RADS + SWV + CEUS) predicted malignancy with an accuracy of 84.9%, sensitivity of 81.0%, and specificity of 86.6%. The modified TI-RADS based on ACR TI-RADS + SWE + CEUS (enhanced pattern) could contribute to reducing the number of biopsies performed on benign nodules and to implementing consistent follow-up in clinical practice.

Biography:

Mai Mazarieb is a MD at Department of General Surgery, Rabin Medical Center, Zarzir, Israel. Her study focused on entitled post-surgical Colorectal Cancer (CRC) surveillance: PET/CT versus CT. Her research interest focus on cancer, surgery

Abstract:

Introduction:  Forty percent of CRC patients will fail, mostly within first two years following primary resection. Early detection of recurrent disease has been reported to improve their survival. The use of PET/CT during the follow-up process is equivocally superior to contrast enhanced CT. This study is a comparison of CT vs. PET/CT.

Methods: Medical records of all patients who had R0 radical colorectal surgery for Stage 1-3 disease between 1.2000 and 1.2016 were retrospectively reviewed. All patient who experienced recurrence and had both abdominal and/or chest CT scans followed by PET/CT within 60 days, were included in the study. A radiologist reviewed all images for disease recurrence. Findings consistent with recurrent disease were compared between the two modalities.

Results: Of 35 CT images 14 identified lung nodules; 10 of these 14 were confirmed malignant by FDG uptake. .9 CT images identified liver lesions, all were called “cystic”; PET/CT identified 10 liver cases; 6 of these 10 cases were called disease recurrence to the liver. One case was not demonstrated by CT while PET/CT did identify a disease recurrence in the liver. CT and PET/ CT both identified 7 peritoneal cases, but only 3 cases; were FDG avid (see table). PET/CT identified all anastomotic recurrences (N=4), these were noted only 3 times on CT.

Conclusions: A notable proportion of patients with negative findings on routine CT performed presented with a positive PET/CT. PET/CT should be employed in the follow-up protocol and replaced the CT.